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It is characterized by an overproduction of nail plate localized within the tumor's topography, resulting in thickening, xanthonychia, and transverse and longitudinal hypercurvature of the nail plate.45 A swelling of the proximal fold can be observed, beneath which the tumor is located

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His subsequent studies etablished the widespread presence of philothion in animal and plant tissues, and led to the conclusion that the compound contained cysteine that can undergo reversible oxidation to a disulfide form in the presence of oxygen (de Rey-Pailhade, 1928)