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However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use

A pragmatic alternative is to prepare smaller vials from your reconstituted stock and freeze them as single-use aliquots at 20C, minimizing repeated freeze-thaw exposure to your main vial

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In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%