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Considerations for Patients with Malabsorption Disorders Those with malabsorption issues, like celiac disease or Crohns disease, might need more B12

How long B12 shots take to work depends on your B12 levels when you receive the injection, but you can expect to see improved energy, mental clarity, sleep, and other benefits anywhere from 12-48 hours after treatment

It acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, enzymes that are critical for one-carbon metabolism as well as the catabolism of odd-chain fatty acids and branched-chain amino acids (Rucker et al., 2007)

If so, consider fortified non-dairy alternatives