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The World Health Organization has also previously cited several health concerns associated with vaping, pointing out that: The long-term effects are unknown Nicotine in the liquid that is vapourised in an e-cigarette is addictive Users replacing the liquid in refillable e-cigarettes might spill the product on their skin, possibly leading to nicotine poisoning Some sweeter flavours of e-cigarettes are irritants, potentially causing inflammation of the airways

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These sex differences have declined since at least 1980, driven by smoking-attributable mortality, which tended to decline in males and increase in females overall