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Serious risks include systemic infections in immunocompromised patients, and the FDA advises against use in critically ill patients and preterm infants due to potential harm

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The mechanism of action involves several complementary effects: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin is released only when blood sugar levels are elevated Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , which helps moderate the rise in blood sugar after meals Reducing appetite through effects on brain centres that regulate hunger Ozempic is administered as a once-weekly subcutaneous injection using a pre-filled pen device