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Approximately 5% of individuals stopped taking the medication because of negative reactions (Sanchez-Rangel and Inzucchi, 2017

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[2] The human ALS-deficiency picture reinforces the same point from the opposite direction: profoundly reduced circulating IGF-1 is compatible with near-normal growth when local tissue IGF-1 is intact, underscoring that the circulating pool and the local pool are not simply interchangeable