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No causal link has been established in humans for retatrutide or other GLP-1-based medicines

In fact, research suggests that after stopping GLP-1 medications, around 60% of people will regain the weight theyve lost

Keap1 responds to oxidative stress signals by freeing Nrf2

Addressing weight regain requires a comprehensive approach that considers both physiological mechanisms and lifestyle factors, often necessitating renewed medical intervention alongside behavioural support to optimise long-term outcomes and preserve the metabolic benefits achieved through surgery

According to ClinicalTrials.gov, three human clinical trials are investigating the potential effects of a GLP1 receptor agonist against tobacco use disorder (Table 2), and one randomized clinical pilot trial has investigated the effects of exenatide, 2.0 mg once weekly, in combination with transdermal nicotine replacement therapy on smoking cessation