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Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis

Individuals with certain autoimmune diseases, where immune modulation by glutathione could have unpredictable effects

it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 50,51,52

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