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Nanomaterials, particularly silver and titanium dioxide NPs, have been shown to accumulate in the liver and kidneys of fish, negatively affecting their physiologic functioning and increasing the mortality rate

This is often due to the way stimulants increase neurotransmitters like dopamine and norepinephrine

This anti-metastatic effect was due to the activation of the SP1/caveoli-1 signalling pathway ( Finally, Oldenlandia diffusa (Willd.) Roxb

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159 If symptoms continue despite these measures, dose de-escalation is considered because the incidence and severity of adverse effects are dose-dependent, with higher doses associated with a higher incidence and severity of complaints