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Clinical trial data demonstrates that gastrointestinal side effects typically peak during the first few weeks after starting treatment or increasing the dose, then gradually diminish

The starting dose considerations are especially important for migraine-prone individuals

For plan sponsors, these differences highlight the importance of balancing efficacy with tolerability, as side-effects can directly influence adherence and total cost of therapy

Xiao ZP, Wang XD, Peng ZY, Huang S, Yang P, Li QS, Zhou LH, Hu XJ, Wu LJ, Zhou Y, Zhu HL (2012) Molecular docking, kinetics study, and structure-activity relationship analysis of quercetin and its analogous as Helicobacter pylori urease inhibitors

Deterioration of the incretin effect leads to a decreased ability to secrete insulin and hyperglycemia, which may exacerbate insulin resistance [14]