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Abbreviations ACEIs: Angiotensin-converting enzyme inhibitors ApoE: Apolipoprotein E-deficient Ang II: Angiotensin II AS: Atherosclerosis AT2R: Angiotensin II receptor type 2 BNP: Brain natriuretic peptide CAT: Catalase CCBs: Calcium channel blockers CH: Cardiac hypertrophy cIMT: Carotid intima-media thickness DAMPs: Damage-associated molecular patterns DDS: Diallyl disulfide DOX: Doxorubicin DTS: Diallyl trisulfide eNOS: Endothelial nitric oxide synthase GSH-Px: Glutathione peroxidase H 2 O 2 : Hydrogen peroxide H 2 S: Hydrogen sulfide Hcy: Homocysteine HF: Heart failure HR: Hypoxia-reoxygenation IL-6: Interleukin-6 JNK: Jun N-terminal kinase LDL-C: Low-density lipoprotein cholesterol LDLR: Low-density lipoprotein receptor LXR: Liver X receptor alpha MDA: Malondialdehyde mTOR: Mammalian target of rapamycin MI: Myocardial infarction MI/R: Myocardial ischemiareperfusion MTX: Methotrexate NF-B: Nuclear factor kappa B NLRP3: NOD-like receptor pyrin domain-containing protein 3 NO-sGC-cGMP: NO-soluble guanylate cyclase-cyclic guanosine monophosphate PCSK9: Proprotein convertase subtilisin/kexin type 9 PGI2-AC-cAMP: Prostacyclin-adenylyl cyclase-cyclic adenosine monophosphate PPAR: Peroxisome proliferator-activated receptor Prx: Peroxidase ROS: Reactive oxygen speciesc SAC: S-allyl cysteine SOD: Superoxide dismutase SREBP2: Sterol regulatory element binding proteins 2 TC: Total cholesterol TG: Triglycerides TGF-: Transforming growth factor- TLR4: Toll-like receptor 4 TMAO: Trimethylamine- N -oxide TNF-: Tumor necrosis factor-alpha References Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, et al

Novo Nordisk, the maker of Wegovy and Ozempic, declined a request for comment