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This impairment can happen because the body releases less GLP-1, breaks it down too quickly, or does not respond to it effectively

NICE guidelines recommend lifestyle modifications (such as weight loss, avoiding trigger foods, and eating smaller meals) and proton pump inhibitors (PPIs) as first-line management for GORD

Nearly half of patients who discontinued semaglutide or tirzepatide cited cost or insurance issues

Storage guidelines Lyophilized (powder) form: Temperature: Store at -20 degrees Celsius for long-term storage, or 2 to 8 degrees Celsius (refrigerator) for short-term storage up to several months Light: Protect from direct light

The projected data are shown in Supplementary Fig