demonstrated the involvement of the Wnt/-catenin and RANK/RANKL/(OPG) axis in PWS by showing high levels of RANK-L and low levels of OPG in both children and adults with PWS, with a bias towards RANK-L ( Recently, irisin, a myokine secreted by the muscle, has sparked great interest due to its involvement in bone, adipose tissue, and brain homeostasis
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The main function of WAT is to store excess energy in the form of fatty acids (TGs) or to release glycerol and FFAs as energy reservoirs to fuel effector organs, skeletal muscle and BAT when required [49]
