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The temperature-dependent increase in the rate of hydrolysis of pNPB and pNPPal is likely to be extremely complex, involving contributions from the increase in k T (Arrhenius behaviour), as well as from temperature-induced reduction in viscosity, leading to increased substrate and product diffusion rates

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The reticulocyte count is increased and may reach peaks of 30% or greater, with an elevated percentage of the immature reticulocyte fraction, reflecting a prompt and effective bone marrow response

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A recent case report suggests that such medications can influence brain regions involved in emotional regulation and potentially trigger or worsen severe depressive symptoms