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These advantages include improved pharmacokinetics and bioavailability in vivo , as well as the ability to fine-tune dual agonist potency and efficacy through selective modifications of amino acid residues that are important to GPCR activation

10.1056/nejmoa1603827 58 MartnezJ.JohnsonC

It is a known, though rare, potential side effect of GLP-1 medications

For diabetes management, the target HbA1c is typically below 7% for most adults, though individualized targets may be appropriate based on age, comorbidities, and hypoglycemia risk