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Individuals with the following conditions face severe and life-threatening risks and should avoid coffee enemas : Digestive conditions, including Crohns disease, Ulcerative Colitis and Diverticulitis A history of bowel surgery Congestive heart failure Intestinal tumors Gastrointestinal cancer Blood vessel disease Kidney, heart, and liver disease Severe hemorrhoids Abdominal hernias Anemia Allergy to coffee Women who are pregnant or nursing should not undertake a coffee enema

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They could decrease the expression and phosphorylation of epidermal growth factor receptor (EGFR), Met, Akt, and NF-B in cervical cancer cells, and totally inhibit the EGFR/Met-Akt/NF-B signaling pathway activated by hepatocyte growth factor (HGF) and epidermal growth factor (EGF) (69)