Interestingly, some reports suggest retatrutide's balanced receptor activation may produce fewer GI issues than equivalent weight loss from single agonists, though this requires further investigation
Critical Reviews in Food Science and Nutrition, 63 (20), 46184635
Biochemistry 85 , 11781190 (2020)
More serious but less common adverse effects observed across the incretin drug class and under investigation for retatrutide include: Pancreatitis : Seek urgent medical attention if you experience severe, persistent abdominal pain, particularly if it radiates to the back
In Quebec, where one in four adults is obese, the current cost of these new drugs (approximately $500 per month) would involve an annual expenditure of several hundred million dollars (in the United States the situation is even worse: the cost of a 72-week course of tirzepatide (15 mg/week) is approximately US$17,000, while the 68-week treatment with semaglutide (2.4 mg/week) is nearly US$23,000!)