The secondary endpoint included changes in glucose, insulin, HOMA-IR, blood pressure, lipid profiles, uric acid, free fatty acids, hepatic profile, and the sensation of fatigue and hunger
BDP has no conflicts of interest to disclose
The landscape is also shaped by manufacturing capacity concerns: At last weeks Semafor World Economy, Eli Lillys CEO framed new oral pills as a huge scale solution for global supply constraints, saying that no matter how hard we want to try, we cannot reach the planet with traditional injectable treatments.
There's also data suggesting that in some cases, people who take GLP-1s for several years can start to experience a waning effect - perhaps a drug resistance - where they start to regain some weight, even while taking the medication
Reduction in serum leptin and IGF-1 but preserved T-lymphocyte numbers and activation after a ketogenic diet in rheumatoid arthritis patients