hims glp 1 reddit just posted this update for GLP-1 users going forward : r/HersWeightloss Considering Hims GLP-1 but :

RNAseq data have been deposited at GEO (accession GSE297747)

However, no significant increase in the risk of serious biliary tract disease has been observed

Interestingly, certain bitter compounds, such as denatonium benzoate (DB), have been found to stimulate the secretion of insulin, glucagon, somatostatin, and GLP-1 from pancreatic islets independently of glucose levels

Gonzlez-Fuentes J, Plaza-Oliver M, Santander-Ortega MJ, Lozano MV (2024) Understanding the role of the structure of single-stimuli hybrid systems on their behaviour as platforms for colonic delivery

Leaky gut syndrome is a result of increased gut permeability