In our experience, transitioning directly to subcutaneous semaglutide 1 mg once weekly from another GLP-1 receptor agonist can be associated with nausea or GI disturbance
The medication does not appear in semen at levels that would affect a partner or developing pregnancy
Payers in markets with formal HTA processes (NICE in the UK, G-BA in Germany, HAS in France) routinely restrict reimbursement or demand price concessions for drugs approved on surrogate endpoints without confirmatory OS data
Oxidative stress can also affect skin health due to the deterioration of the anti-oxidative mechanisms and the increased production of reactive oxygen species (ROS), causing DNA damage and oxidation of the cellular membranes
In addition, mood abnormalities are common [2], particularly despair and anxiety [23], whereas 58.4% of Long COVID patients have cognitive impairment and 3451-78% have memory problems, particularly memory loss [2, 18, 22, 104, 108]
