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FTO removes the m 6 A mark of RRM2 mRNA through demethylation, blocks YTHDF2 binding, and causes mRNA to be degraded by the CCR4-NOT complex

After 11 days of ML226 treatment, we observed a marked increase in unsaturated tri- and diglycerides, with a downregulation of saturated glycerides (Extended Data Fig

Cells were then lysed in pre-chilled RIPA lysis buffer with protease/phosphatase inhibitors

Clinical pilot studies (e.g., Kumar et al.) showed improved mitochondrial function, lowered oxidative stress, and better insulin sensitivity in older adults with GlyNAC

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