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Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas

These findings held true even for patients with existing kidney impairment at baseline, suggesting GLP-1 therapy addresses a fundamental mechanism of renal disease rather than masking surface symptoms

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Studies highlight roles in signaling kinetics and systemic processes in preclinical settings

Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency