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In larger doses, they cause over-excitement of neurons

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Lack of awareness and education among the general public A final implementation barrier described by a majority of stakeholders was a lack of awareness and education of the T21 law among the general public

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Kleinjan M, van den Eijnden RJ, Engels RC: Adolescents rationalizations to continue smoking: The role of disengagement beliefs and nicotine dependence in smoking cessation