Extensive evidence has confirmed that specific ferroptosis-related metabolic signals or byproducts were involved in the function, viability, and differentiation of multiple T-cell subgroups, impacting their reactivity to inflammation, infection and tumor immunity ( As was reported recently in tumor immunity, the ferroptotic interaction between CD8+ T cell-secreted IFN- and tumor cells is known to induce the elicitation of tumor ferroptosis and reinforcement of anti-tumor activity ( Besides, regulatory T (Treg) cells with a deletion of PDK1 have been implicated in the generation of excessive ROS, which consequently leads to amplified ferroptosis of themselves ( In vitro study corroborated that the suppression of the ROS/TXNIP/HIF-1 pathway, which was presumably associated with the mitochondrial dysfunction in ferroptosis, fosters the ratio of retina-specific Treg cells, notably attenuating ocular inflammation and optic disc edema ( Certain regulators of ferroptosis have emerged as vital contributors in the disruption of the proliferation and survival of CD4+ T cells that potentially exacerbate both tumor progression and pathogen invasion ( 2.4 Other immune cells The interplay between other immune cells and ferroptosis in ocular immune microenvironment remains to be thoroughly explored, although some bioinformatics analyses have commenced in these domains
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J Family Med Primary Care 8(12):39203924 Adisuri DS, Madhavan P, Chong PP, Nathan S (2024) Antifungal activity of piperine-based nanoemulsion against Candida spp
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