Water retention can still occur due to other factors like salt intake, hydration levels, or hormonal changes
Semaglutide does seem to have fewer side effects than Liraglutide in total (perhaps due to the fact that it is only injected once a week instead of daily), but the potency of Semaglutide may mean that these side effects could be more intense
Eating smaller, more frequent meals throughout the day rather than large meals can help reduce nausea severity
As such, GLP-1 is present in circulation at low levels in fasting humans and begins to increase in the first few minutes after nutrient ingestion, peaking ~6090 min postprandially at ~15 pmol/L of active GLP-1 97,100
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