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A severe adverse reaction is a medical event that: requires emergency care or hospitalization causes long-term or permanent damage significantly disrupts normal bodily function increases risk of disability or death Severe adverse reactions to FDA-approved GLP-1 receptor agonists (like Ozempic, Wegovy, and Mounjaro) include acute gallbladder disease, pancreatitis, kidney failure, severe hypoglycemia (when combined with other medications), and severe gastrointestinal issues such as vomiting and diarrhea