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[4] [5] By activating GLP-1 receptors, retatrutide is thought to enhance insulin secretion in a glucose-dependent manner, suppress glucagon release, and reduce appetite by acting on satiety centres in the brain

One clinical study found that people on Lexapro for 9 months gained an average of 2.4 pounds

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Djouhri, L., Malki, M

In one study, people who switched to tirzepatide after being on another GLP-1 medication continued to lose weight (about 2.1 kg more in 12 weeks) instead of plateauing