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Dorr RT, Lines R, Levine N, et al

Fischer, A

Second to quitting tobacco use, it remains the single most powerful lifestyle intervention for heart health

In addition to the aforementioned remodelling of the metabolome in fatigue-associated diseases, including long COVID, acylcarnitines have emerged as important modulators of CNS function [29]: In both mice and humans, different classes of acylcarnitines have been found to be altered in either mouse models of depression or humans with MDD, with associations to symptom severity and also treatment response, as reviewed by Liu et al

However, the latter mechanism is not supported by our experimental findings for two reasons: first, only didepsipeptides and a multiple thereof were found by means of UPLC-TOF MS and not even traces of depsipeptide intermediates showing uneven numbers of monomers were detectable