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Abstract Caudatin is a C 21 steroidal glycoside isolated from many species of the genus Cynanchum , has been utilized by traditional medicine to treat cancer and inflammation which is increasingly being considered a drug candidate because of the pharmacological activity it displays
Verbal consent was obtained via phone and has been appropriately documented
The structures of some isocereulides differed from that of cereulide by substitution of L- O -Val by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D- O -Leu by D- O -Val (isocereulide B), thus indicating a relaxed substrate specificity of the A domains and an inefficient proof reading by CesT 18
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AE incidence was assessed as a supportive secondary safety endpoint in each trial
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