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Contraindications and Precautions Thiazolidinediones are contraindicated in patients with (8): Heart failure Moderate to severe hepatic impairment Active or history of bladder cancer Pregnancy High-risk fracture Cytochrome CYP 2C8 and CYP 3A4 Adverse Effects and Black Box Warnings Thiazolidinediones have several adverse effects, including (8): Edema Congestive heart failure Weight gain Decreased bone density, leading to fractures Bladder cancer Hepatotoxicity Diabetic macular edema Increased ovulation and teratogenic effects Thiazolidinediones have a black box warning of congestive heart failure and myocardial ischemia

When your B12 levels are low, hair can become weaker, more brittle and prone to shedding

Serious symptoms can include dizziness, nausea and brain zaps or shock-like sensations

The nature of the substance being injected can vary, depending on the condition being treated, and may include vitamins, herbal pain relief, or other homeopathic remedies

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