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It modulates neurotransmitter systems including dopamine and serotonin

This pattern suggests DSIP's potential influence on the opioidergic system, possibly contributing to mechanisms of stress mitigation or adaptation

and stress signaling pathways, related to Fig

IGF Binding Proteins and Bioavailability The mechanism underlying this enhanced potency relates to IGF-1's complex regulatory system involving IGF binding proteins (IGFBPs), a family of six high-affinity binding proteins (IGFBP-1 through IGFBP-6) that normally sequester the vast majority of circulating IGF-1 and regulate its bioavailability, half-life, and access to cell surface IGF-1 receptors