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RYBELSUS is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Payers are signaling willingness to reimburse premium-priced multi-agonists if cardiovascular or renal benefits materialize, a possibility under investigation in ongoing SURMOUNT-5 and TRIUMPH-2 outcome studies

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Only two studies were found evaluating the effect of combining a PDE-5 inhibitor with L-arginine for erectile dysfunction and comparing with PDE-5 inhibitor alone: one for sildenafil15 and one for vardenafil

doi: 10.1249/MSS.0b013e3181dbacab