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It is a 16-amino-acid peptide with the sequence MRWQEMGYIFYPRKLR , discovered as part of a class of mitochondrial-encoded peptides involved in metabolic homeostasis

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A randomized clinical trial (RCT) demonstrated that high-dose riboflavin supplementation (400 mg/d) could decrease the attack frequency, duration, severity, and number of headache days in adults with migraine, after 3 months