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This makes it the first "triple agonist" to reach human clinical trials

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surmount-1 tirzepatide trial obesity without diabetes Comparative Efficacy and Safety of in Asian and NonAsian Adults With Diabetes: A Systematic Review and MetaAnalysis - KamrulHasan - 2026 - Endocrinology, & Metabolism SURMOUNT-1 (NEJM 2022) tested tirzepatide
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