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Methodological quality appraisal Two independent authors evaluated the risk of bias for each study using the Cochrane Risk of Bias Tool 1.0 [43], achieving an inter-rater reliability of 0.85

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Figure 2: Shows the distribution of average weight change relative to weight at the start of GLP-1 therapy for nonresponders and responders over five different weight recording periods Key takeaways Nonresponders, who did not initially experience significant weight loss on GLP-1s, begin to achieve increased weight loss success in the earlier stages of the program

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