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Recovery of ergosterol and vitamin D2 from mushroom waste-potential valorization by food and pharmaceutical industries

Chronic studies in rats given 200 mg/kg body weight per day for 104 weeks, dogs given 20 mg/kg PO x 84 days, cats given 40-65 mg/kg for 118 days did not produce any signs of toxicity (blood testing, liver histology)

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The discrepancy between this study and the data herein may reflect the heterogeneous nature of CD and disease severity between the patient donors (the current study used monocytes from individuals with mild-to-moderate CD), the mechanisms of action of the various pro-death stimuli, or differences in apoptotic versus non-apoptotic death in macrophages

343 Reduced astrocytic homoeostatic support is also evidenced by the loss of endfeet polarisation of AQP4 344 and decreased expression of monocarboxylate transporter 1 345 responsive for lactate supply of neurones