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In line with NICE NG203 (Chronic kidney disease: assessment and management), routine referral to nephrology is typically considered at eGFR below 30 mL/min/1.73 m, or in the presence of rapidly declining eGFR, significant proteinuria (ACR 70 mg/mmol), or other complex features

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

Together, these external sources reinforce the generalizability and clinical importance of our findings: (1) weight regain is a consistent outcome upon cessation of anti-obesity therapy, (2) the extent of rebound correlates with the initial magnitude of weight loss, and (3) long-term efficacy demands a multidisciplinary and continuous management strategy

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Verdict at a Glance Semaglutide is the established standard with three FDA approvals, massive clinical evidence, and proven cardiovascular outcomes