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10.1074/jbc.275.48.37524

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Researchers have suggested that Melanotan 1 may exhibit a particular specificity towards MC1R, ostensibly enhancing melanin production, which, in turn, is thought to result in a tanned appearance of the skin tissues

This review attempts to provide some mechanistic insight (Figures 13) into how the bi-directional network between the gut microbiota and the brain can not only protect but also trigger and aid chronic gut inflammation, promote a global pro-inflammatory state, modify and contribute to protein misfolding processes, dysregulate the autophagic-lysosomal protein clearance mechanism, differentiate T-cell subsets to facilitate a deleterious autoimmune response, and finally modulate immune recruitment and BBB status

F.VaduganathanM.RosenstockJ.et al (2020)