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Although generally considered as a benign tumour, it can invade the adjacent muscle and bone, causing destruction of the involved site

The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain

Notably, key transcription factors (e.g., Nrf2 and HIF-1) act as critical regulatory checkpoints within this network: Nrf2 inhibits ferroptosis and inflammation by upregulating GPX4 and antioxidant enzymes, while HIF-1 exerts a context-dependent dual role, acutely mitigating ferroptosis via Nrf2 activation but promoting fibrosis and sustained ferroptosis when chronically stabilized

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[DOI] [PubMed] [Google Scholar] 46.Sordi B, Vanderwert F, Crupi F, Gesullo F, Zanotti R, Bonadonna P, et al