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6 Formalin-induced nociceptive behavioral test Male Sprague Dawley rats (250~300 g) (n = 35) were randomly divided into the control (n = 7), 5 mg/kg morphine (n = 7) and BPC-157 groups (n = 21) to establish the inflammatory pain model and conduct the behavior test

This might be a potential connection to GM and thyroid regulation suggested initially by the Harries (1923) more than hundred years back (Harries 1923)

Multiple studies have shown that diabetes is associated with cognitive impairment, in which HO-1 as an important antioxidant enzyme, plays an important role in protecting against apoptosis, inflammation, and oxidative stress in diabetic cognitive dysfunction [162,163,164]

Similarly, intranasal corticosteroids failed to prevent the oxidative burden produced by intranasal ragweed allergen challenge [114]

doi: 10.1194/jlr.M500290-JLR200