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Growth hormone promotes protein synthesis, supports nitrogen retention, and stimulates IGF-1 production, all of which counteract the catabolic signals that caloric deficit creates

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Statistical analysis For animal studies, sample sizes ( n = 5 per group, 3 in the tirzepatide-treated group) were determined based on prior in-house experience and previous studies using similar mouse models to ensure adequate power to detect biologically relevant effects

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Cardiac arrhythmias Trials also reported a small number of cases of cardiac arrhythmias, including supraventricular arrhythmias and prolonged QT syndrome

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