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Reported outcomes in animal studies of FOXO4-DRI and related senolytic approaches include improved markers of healthspan, such as better activity levels and improved tissue repair signals, alongside reductions in senescence markers

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The establishment and preservation of the BBB are intricate cooperative processes, hinging on the synergistic actions among the constituent cells of the neurovascular unit (NVU)endothelial cells (ECs), pericytes, astrocytes, extracellular matrix, and neurons (Fig