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Although these clinical studies did not report the mechanisms underlying the renal graft protection by ALA, it is not wrong to suggest that the protective mechanisms by ALA against renal IRI as discussed in section 3.2 above, account for the observed renal graft protection and the improved outcomes of kidney transplantation since IRI is a major contributor to the development of post-transplant complications including renal graft rejection

doi: 10.3390/medicina57101030 34 MaesMTwiskFNM

Next, the sample was dried with a centrifugal concentrator dryer

SeMet treatment elevated the levels of p53 and REF1 proteins and induced their interaction with BRCA1 137 , resulting in the activation of DNA repair pathways

Conceptually, this mirrors Selyes earlier stress theory [59,60]