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We and others have observed that enhanced de novo synthesis of serine and glycine from glucose reduces the reliance of cells on extracellular sources [43, 99]

Halprin KM, Ohkawara A

The deficiency worsens with age and is accelerated by chronic illness, medications, and environmental toxins

For CME_a, the key residues in the C1 region, N259 and E255, are crucial for its binding, further emphasizing the importance of the C1 region in mTYR (Table 4)