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Con la implementacin de esta terapia se empezaron a conocer las complicaciones asociadas con hiperglucemia crnica como alteraciones microvasculares (retinopata, neuropata y nefropata), y macrovasculares (angina, infarto, accidente cerebrovasculares)

Neeland, Linge, and Birkenfeld (2024), writing in Diabetes, Obesity and Metabolism , conclude that skeletal muscle changes with GLP-1 receptor agonist treatment appear adaptive: reductions in muscle volume are commensurate with what is expected given aging, disease status, and weight loss achieved, and improvements in insulin sensitivity and muscle fat infiltration likely contribute to improved muscle quality