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A retrospective study showed that 26% of patients responding to conventional CVS prophylactic therapy with tricyclic antidepressants, antiepileptic medications such as topiramate, and/ or mitochondrial supplements had side effects including behavioral changes, nightmares, and increased somnolence8

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GLP-1 medications may help lower blood pressure in some patients, with clinical trials showing average systolic reductions of 25 mmHg, though individual responses vary considerably