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In the dorsolateral prefrontal cortex, KYN, 3-HK, anthranylic acid, and 3-HAA were elevated in both grey and white matter, whereas TRP, KYNA, and QA increases were restricted to white matter [237]

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For orthotopic liver tumor models, the Hepa16 cells (5 10 6 ) were suspended in 25 L of Matrigel (Sigma-Aldrich) and inoculated into the liver parenchyma of the left lobe for in situ liver tumor model ( n = 6)

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