The medication does the suppressing
Semaglutide works by activating GLP-1 receptors in your brain and pancreas, suppressing hunger signals and improving blood sugar controlmechanisms that address the biological changes pregnancy creates
In terms of achievement of HbA1c target, 81% and 97% of patients treated with tirzepatide reached an HbA1c less than 7%, while 71% and 95% of patients achieved a HbA1c of less than 6.5%
8,14,15 Although most approved GLP-1RAs and co-agonists have not yielded satisfactory results in histological endpoint clinical trials, the future of managing and treating MASLD holds promise
Ultimately, the decision between simultaneous initiation and sequential add-on therapy should be individualized, considering patient-specific factors such as comorbidities, baseline kidney function, and treatment goals