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IGF-1 can activate matrix metalloproteinases through both AKT and MAPK pathways subsequently activating TGF1 leading to nuclear translocation of -catenin and EMT [112]

After binding to ACE2 and/or NRP1 receptors, the S-protein is proteolytically pre-activated by human proprotein convertase furin 66

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doi: 10.1093/infdis/jiac136 [DOI] [PMC free article] [PubMed] [Google Scholar] 8