Disclosures: Erick Cruz Grave: Nothing to Disclose, Connie Chan: Nothing to Disclose, Michael Corwin: Corcept Therapeutics: Consultant, Richard Dean: Nothing to Disclose, Sandeep Dhaliwal: Nothing to Disclose, Maryam Yazdanfar: Nothing to Disclose, Christopher Bowlus: Calliditas: Grant/Research Support, ChemoMab: Grant/Research Support, ChemoMab: Consultant, COUR Phamaceuticals: Grant/Research Support, Cymabay: Grant/Research Support, Cymabay: Consultant, Cymabay: Consultant, Gilead: Grant/Research Support, GSK Pharmaceuticals: Grant/Research Support, GSK Pharmaceuticals: Consultant, Hanmi: Grant/Research Support, Intercept: Grant/Research Support, Invea Therapeutics: Consultant, Ipsen: Grant/Research Support, Ipsen: Consultant, Mirum: Grant/Research Support, NGM Bio: Consultant, Novartis: Grant/Research Support, Novo Nordisk: Grant/Research Support, Pliant Therapeutics: Grant/Research Support, Pliant Therapeutics: Consultant, Viking Therapeutics: Grant/Research Support, Zydus Therapeutics: Grant/Research Support 2344 SIGNIFICANCE OF HETEROGENEOUS BILIARY EPITHELIAL SENESCENCE AS A POSSIBLE TARGET OF NEW THERAPIES IN PRIMARY BILIARY CHOLANGITIS Motoko Sasaki 1 Yasunori Sato 1 Yasuni Nakanuma 2 , 1 Kanazawa university, 2 Fukui Saiseikai Hospital Background: New therapeutic strategies are demanded for the patients with primary biliary cholangitis (PBC) showing inadequate response for ursodeoxycholic acid (UDCA) therapy

In examining mortality, 1,605 G1 patients experienced death compared to 1,058 in the G2
Leptin transport across the blood-brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor gene
to store both opened and unopened pens
Wegovy is a glucagon-like peptide-1 receptor agonist (also known as GLP-1 receptor agonist or GLP-1 RA), which bagged US Food and Drug Administrations approval as a treatment for obesity in June 2021